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Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

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dc.contributor.author Baron, Raluca-Ioana
dc.contributor.author Duceac, Ioana-Alexandra
dc.contributor.author Morariu, Simona
dc.contributor.author Bostănaru, Andra-Cristina
dc.contributor.author Coseri, Sergiu
dc.date.accessioned 2023-04-24T12:34:28Z
dc.date.available 2023-04-24T12:34:28Z
dc.date.issued 2022-11-09
dc.identifier.citation Baron, Raluca Ioana, Ioana A. Duceac, Simona Morariu, Andra-Cristina Bostănaru-Iliescu, and Sergiu Coseri. 2022. "Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings" Gels 8, no. 11: 726. https://doi.org/10.3390/gels8110726. en_US
dc.identifier.uri https://www.mdpi.com/2310-2861/8/11/726
dc.identifier.uri https://repository.uaiasi.ro/xmlui/handle/20.500.12811/3204
dc.description.abstract The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights CC BY 4.0
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Schiff base en_US
dc.subject acetal bonds en_US
dc.subject self-healing en_US
dc.subject mechanical stability en_US
dc.title Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings en_US
dc.type Article en_US
dc.author.affiliation Raluca Ioana Baron , Ioana A. Duceac, Sergiu Coseri, Department of Polyaddition and Photochemistry, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania
dc.author.affiliation Simona Morariu, Department of Natural Polymers, Bioactive and Biocompatible Materials, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania
dc.author.affiliation Andra-Cristina Bostănaru-Iliescu, Laboratory of Antimicrobial Chemotherapy, “Ion Ionescu de la Brad” University of Life Sciences, 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania
dc.publicationName Gels
dc.volume 8
dc.issue 11
dc.publicationDate 2022
dc.identifier.eissn 2310-2861
dc.identifier.doi https://doi.org/10.3390/gels8110726


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