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Apiaceae essential oils: boosters of terbinafine activity against dermatophytes and potent anti-inflammatory effectors

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dc.contributor.author Trifan, Adriana
dc.contributor.author Luca, Simon-Vlad
dc.contributor.author Bostănaru, Andra-Cristina
dc.contributor.author Brebu, Mihai
dc.contributor.author Jităreanu, Alexandra
dc.contributor.author Cristina, Romeo-Teodor
dc.contributor.author Skalicka Woźniak, Krystyna
dc.contributor.author Granica, Sebastian
dc.contributor.author Czerwińska, Monika
dc.contributor.author Kruk, Aleksandra
dc.contributor.author Greige Gerges, Hélène
dc.contributor.author Sieniawska, Elwira
dc.contributor.author Mareș, Mihai
dc.date.accessioned 2023-04-11T10:34:42Z
dc.date.available 2023-04-11T10:34:42Z
dc.date.issued 2021-11-04
dc.identifier.citation Trifan, Adriana, Simon Vlad Luca, Andra-Cristina Bostănaru, Mihai Brebu, Alexandra Jităreanu, Romeo-Teodor Cristina, Krystyna Skalicka-Woźniak et al. 2021. " Apiaceae essential oils: boosters of terbinafine activity against dermatophytes and potent anti-inflammatory effectors". Plants 10 (11): 2378. https://doi.org/10.3390/plants10112378. en_US
dc.identifier.issn 2223-7747
dc.identifier.uri https://repository.uaiasi.ro/xmlui/handle/20.500.12811/3167
dc.description.abstract Dermatophyte infections represent an important public health concern, affecting up to 25% of the world’s population. Trichophyton rubrum and T. mentagrophytes are the predominant dermatophytes in cutaneous infections, with a prevalence accounting for 70% of dermatophytoses. Although terbinafine represents the preferred treatment, its clinical use is hampered by side effects, drug– drug interactions, and the emergence of resistant clinical isolates. Combination therapy, associating terbinafine and essential oils (EOs), represents a promising strategy in the treatment of dermatophytosis. In this study, we screened the potential of selected Apiaceae EOs (ajowan, coriander, caraway, and anise) to improve the antifungal activity of terbinafine against T. rubrum ATCC 28188 and T. mentagrophytes ATCC 9533. The chemical profile of EOs was analyzed by gas chromatography. The minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of EOs/main compounds were determined according to EUCAST-AFST guidelines, with minor modifications. The checkerboard microtiter method was used to identify putative synergistic combinations of EOs/main constituents with terbinafine. The influence of EOs on the viability and pro-inflammatory cytokine production (IL-1b, IL-8 and TNF-a) was determined using an ex vivo human neutrophils model. The binary associations of tested EOs with terbinafine were found to be synergistic against T. rubrum, with FICI values of 0.26–0.31. At the tested concentrations (6.25–25 mg/L), EOs did not exert cytotoxic effects towards human neutrophils. Anise EO was the most potent inhibitor of IL-1b release (46.49% inhibition at 25 mg/L), while coriander EO displayed the highest inhibition towards IL-8 and TNF-a production (54.15% and 54.91%, respectively). In conclusion, the synergistic combinations of terbinafine and investigated Apiaceae EOs could be a starting point in the development of novel topical therapies against T. rubrum-related dermatophytosis. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject essential oil en_US
dc.subject Trichophyton rubrum en_US
dc.subject checkerboard assay en_US
dc.subject Coriandrum sativum en_US
dc.subject cytokines en_US
dc.subject Trachyspermum ammi en_US
dc.subject terbinafine en_US
dc.subject Carum carvi en_US
dc.subject synergy en_US
dc.subject Pimpinella anisum en_US
dc.title Apiaceae essential oils: boosters of terbinafine activity against dermatophytes and potent anti-inflammatory effectors en_US
dc.type Article en_US
dc.author.affiliation Adriana Trifan, Simon-Vlad Luca, Department of Pharmacognosy, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania
dc.author.affiliation Simon-Vlad Luca,Biothermodynamics, TUM School of Life and Food Sciences, Technical University of Munich, 85354 Freising, Germany
dc.author.affiliation Andra-Cristina Bostănaru, Mihai Mareș, Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” Iasi University of Life Sciences, 700489 Iasi, Romania
dc.author.affiliation Mihai Brebu, Physical Chemistry of Polymers Laboratory, Petru Poni Institute of Macromolecular Chemistry, 700481 Iasi, Romania
dc.author.affiliation Alexandra Jităreanu, Department of Toxicology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania
dc.author.affiliation Romeo-Teodor Cristina, Department of Pharmacology, The Banat University of Agricultural Sciences and Veterinary Medicine, 300645 Timisoara, Romania
dc.author.affiliation Krystyna Skalicka Woźniak, Elwira Sieniawska, Department of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, Poland
dc.author.affiliation Sebastian Granica, Aleksandra Kruk, Microbiota Lab, Centre for Preclinical Studies, Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, 02-097 Warsaw, Poland
dc.author.affiliation Monika Czerwińska, Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
dc.author.affiliation Monika Czerwińska, Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland
dc.author.affiliation Hélène Greige-Gerges, Bioactive Molecules Research Laboratory, Department of Chemistry and Biochemistry, Faculty of Sciences, Section II, Lebanese University, Jdaidet el-Matn B.P. 90656, Lebanon
dc.publicationName Plants
dc.volume 10
dc.issue 11
dc.publicationDate 2021
dc.identifier.doi 10.3390/plants10112378


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Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)