ALSERepository of Iași University of Life Sciences, ROMANIA

The effects of antidiuretic hormone (vasopressin) administration on the contractility of the arterial preparations in rats compared with pets

Show simple item record

dc.contributor.author Beșchea Chiriac, Sorin-Ioan
dc.contributor.author Hrițcu, Luminița-Diana
dc.contributor.author Boghian, Vasile
dc.contributor.author Solcan, Gheorghe
dc.date.accessioned 2021-10-06T07:54:57Z
dc.date.available 2021-10-06T07:54:57Z
dc.date.issued 2015
dc.identifier.citation Beșchea Chiriac, Sorin Ioan, Luminița Hrițcu, Vasile Boghian, Gheorghe Solcan. 2015. "The effects of antidiuretic hormone (vasopressin) administration on the contractility of the arterial preparations in rats compared with pets". Lucrări Științifice USAMV - Iași Seria Medicină Veterinară 58 (2): 133-138. en_US
dc.identifier.uri https://repository.uaiasi.ro/xmlui/handle/20.500.12811/1887
dc.description.abstract Vasopressin known as antidiuretic hormone is responsible for regulating plasma osmolality and volume. It acts as a neurotransmitter in the brain to control circadian rhythm, thermoregulation, and adrenocorticotrophic hormone release. The therapeutic use of vasopressin has become increasingly important in the critical care environment in the management of cranial diabetes insipidus, bleeding abnormalities, oesophageal variceal haemorrhage, asystolic cardiac arrest, and septic shock. The present study aims toward identifying similarities and differences between the resistance arteries belonging from various mammal species that are most involved in veterinary practice: rats, cats and dogs. Smooth muscle has been studied as circular preparations from rat aorta, cat and dog coronary gastric aorta. Force generation has been studied using isometric transducers while stimulation of preparations was made pharmacologically at various doses. Results were expressed as percentage of inhibition or stimulation of the control contraction. Force generation, frequency and amplitude of spontaneous contraction have been recorded. Administration in isolated preparations where made using desmopressin acetate (Ferring) as vials of 4 mg/ml. The preparation is a synthetic analogue of the natural hormone 8-arginine-vasopressin, as arginine-vasopressine-monoacetatetrihydrate. Dosages varied from 10-12M to10-8M. Several methods have been tried for normalizing maximal isometric force developed by smooth muscle from various locations, vessel dimensions and animal species. We have measured in vitro the amount of force generated by arterial rings harvested from the same areas, very rigorously cleaned of adventice and surrounding tissues and the force, expressed as mN was ratioed to the wet weight of the preparations. The results were statistically investigated using the t-test and ANOVA testing. In preparations of rat aorta and splachnic arteries from cat and dog, the vasopressin induced a tonic contraction, with an aspect of descending plateau. In conclusion, vasopressin contraction has several special characteristics concerning its dynamics. The contractile plateau is kept only for about 10-15 minutes, after which it fades, and new administration in a space of approximately 16 minutes does not induce the initially effect (probable tachyphylaxis). en_US
dc.language.iso en en_US
dc.publisher ”Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, Iași en_US
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject vascular en_US
dc.subject reactivity en_US
dc.subject arterial en_US
dc.subject vasoconstrictor agent en_US
dc.title The effects of antidiuretic hormone (vasopressin) administration on the contractility of the arterial preparations in rats compared with pets en_US
dc.type Article en_US
dc.author.affiliation Sorin Ioan Beșchea Chiriac, Luminița Hrițcu, Vasile Boghian, Gheorghe Solcan University of Agricultural Sciences and Veterinary Medicine “Ion Ionescu de la Brad”, Iași. Faculty of Veterinary Medicine. Departament of Internal Medicine, Iași, Romania
dc.publicationName Lucrări Științifice USAMV - Iași, Seria Medicină Veterinară
dc.volume 58
dc.issue 2
dc.publicationDate 2015
dc.startingPage 133
dc.endingPage 138
dc.identifier.eissn 2393-4603


Files in this item

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)