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Facial regeneration: current status and perspectives

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dc.contributor.author Stoleriu, Gabriela
dc.contributor.author Voicu, Cătălina Maria
dc.contributor.author Brănișteanu, Daciana Elena
dc.contributor.author Manolache, Nicuța
dc.contributor.author Anghel, Lucreția
dc.contributor.author Filip-Ciubotaru, Florina Mihaela
dc.contributor.author Lupu, Vasile Valeriu
dc.date.accessioned 2021-05-12T11:44:40Z
dc.date.available 2021-05-12T11:44:40Z
dc.date.issued 2017
dc.identifier.citation Stoleriu, Gabriela, Cătălina Maria Voicu, Daciana Elena Brănișteanu, Nicuța Manolache, Lucreția Anghel, Florina Mihaela Filip-Ciubotaru, Vasile Valeriu Lupu. 2017. "Facial regeneration: current status and perspectives". Lucrări Științifice USAMV - Iași Seria Medicină Veterinară 60 (4): 517-526. en_US
dc.identifier.uri https://repository.uaiasi.ro/xmlui/handle/20.500.12811/1247
dc.description.abstract Skin aging is a complex biological processes influenced by endogenous and exogenous factors. The primary aim of all skin anti-aging strategies is to reverse the dermal and epidermal signs of photoaging and chronological aging. Healthy and normal functioning skin barrier is an important protector against dehydration, penetration of various microorganisms, allergens, irritants, reactive oxygen species and radiation. The skin barrier may be specifically adjusted to allow penetration of desired substances.Regenerative medicine is the science of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal form and function. It uses cells, tissues, drugs, synthetic biomaterials and devices to help patients heal or regeneration. The reason of different methods of skin regeneration is to increase skin regeneration, elasticity, smoothness, density, macroscopic and microscopic aspect, changing the skin condition. It is necessary to slow down ageing processes on a cellular level concomitantly. We can provide to the skin primary structural constituents, such as collagen, elastin, to prevent the formation of wrinkles, but some products and techniques do promote the natural synthesis of these substances except elastin enhancing. Simultaneously it is necessary to prevent wrinkle formation by reduction of inflammation (topical or systemic antioxidants) in combination with sunscreens and retinoids to enhance their protective effects. An important attention must be accorded to Transforming Growth Factor- β family, other TGF-β-based approaches (Decorin and Mannose 6 Phosphate), modulation of Smad3/Smad7 Signaling, Epidermal Growth Factor family, Fibroblast Growth Factor family, Platelet-Derived Growth Factor family, Granulocyte Macrophage-Colony Stimulating Factor, Connective Tissue Growth Factor, Interleukin 10, Connexins, other approaches under investigation for scar reduction, collagen, fibronectin, laminin, elastin, glycosaminoglycans and other natural biomaterials. Regenerative Aesthetic Dermatology is focused on innovative treatments to support the skin in restoring and regenerating old and/or damaged tissue and thus improving overall skin quality, promoting faster healing while minimizing downtime and side effects for patients. The onset of effects could be instantly after procedure or can be observed gradually increasing over the time (weeks or monthes), as we are determining the skin to help itself. The regenerative treatments are encouraging the skin to build more collagen and elastin itself by bio-stimulation: resurfacing the epidermis (topical drug application, ablative LASERs, Laser radiofrequency resurfacing, ablative radiofrequency, microneedling, plasma skin resurfacing, crystal-free microdermabrasion), the formation of new collagen (IPL, Lasers, radiofrequency, infrared, Jett Plasma Medical, medical needling, mesotherapy, platelet-rich plasma, fillers as hyaluronic acid, HydraFacial MD, Oxygen facial, chemical peels, hormone replacement therapy, autologous and allogeneic stem cells, gene therapy), slow down the visible aging process by helping in the management of certain dynamic facial lines and wrinkles (Botulinum toxin). 518 Resurfacing the skin could be considered as a cancer prophylaxis and aesthetic dermatology is contributing to slowly, healthy, gracefully aging. en_US
dc.language.iso en en_US
dc.publisher ”Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, Iași en_US
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject prevention anti-aging en_US
dc.subject antioxidants en_US
dc.subject regeneration en_US
dc.subject rejuvenation en_US
dc.subject laser en_US
dc.subject IPL en_US
dc.subject peeling en_US
dc.subject fillers en_US
dc.subject botulinum toxin en_US
dc.subject plasma en_US
dc.subject therapy en_US
dc.subject hyaluronic acid en_US
dc.title Facial regeneration: current status and perspectives en_US
dc.type Article en_US
dc.author.affiliation Gabriela Stoleriu, Daciana Elena Brănișteanu, University of Medicine and Pharmacy ”Grigore T. Popa”, Iași, Faculty of Medicine, Department of Dermatology
dc.author.affiliation Gabriela Stoleriu, Nicuța Manolache, "Dunărea de Jos" University of Galați, Faculty of Medicine and Pharmacy, Department of Pharmaceutical Sciences
dc.author.affiliation Cătălina Maria Voicu, Derma Clinique, Iași
dc.author.affiliation Lucreția Anghel, "Dunărea de Jos" University of Galați, Faculty of Medicine and Pharmacy, Department of Medical Clinic
dc.author.affiliation Florina Mihaela Filip-Ciubotaru, University of Medicine and Pharmacy ”Grigore T. Popa”, Iași, Faculty of Medicine, Department of Family Medicine
dc.author.affiliation Vasile Valeriu Lupu, University of Medicine and Pharmacy ”Grigore T. Popa”, Iași, Faculty of Medicine, Pediatrics Department
dc.publicationName Lucrări Științifice USAMV - Iași, Seria Medicină Veterinară
dc.volume 60
dc.issue 4
dc.publicationDate 2017
dc.startingPage 517
dc.endingPage 526
dc.identifier.eissn 2393-4603


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)