Show simple item record Moroșan, Șerban Cozma, Andreea-Paula Dascălu, Mihaela-Anca Pașca, Aurelian-Sorin 2022-11-10T11:43:33Z 2022-11-10T11:43:33Z 2020
dc.identifier.citation Moroșan, Șerban, Andreea Paula Cozma, Mihaela Anca Dascalu, Sorin Pașca. 2020. “Humanized mouse models and human viruses”. Lucrări Ştiinţifice USAMV - Iaşi Seria Medicină Veterinară 63 (3): 235-239. en_US
dc.description.abstract Well-developed mouse models are important for understanding the pathogenesis and progression of immunological response to viral infections in humans. Moreover, to test vaccines, anti-viral drugs and therapeutic agents, mouse models are fundamental for preclinical investigations. Human viruses, however, seldom infect mice due to differences in the cellular receptors used by the viruses for entry, as well as in the innate immune responses in mice and humans. In other words, a species barrier exists when using mouse models for investigating human viral infections. Developing transgenic (Tg) mice models expressing the human genes coding for viral entry receptors and knock-out (KO) mice models devoid of components involved in the innate immune response have, to some extent, overcome this barrier. Humanized mouse models are a third approach, developed by engrafting functional human cells and tissues into immunodeficient mice. With an increase in the advancement of modern techniques used for genetic manipulation, humanized mice have become an important asset. They are becoming indispensable for analyzing human viral diseases since they nearly recapitulate the human disease. These mouse models also serve to test the efficacy of vaccines and antiviral agents. The development of humanized mouse models offers a preclinical in vivo platform for further characterization of human viral infections and human immune responses triggered by these virus particles. This review highlights recent progress in utilizing humanized mice to decipher human specific immune responses against viral tropism. en_US
dc.language.iso en en_US
dc.publisher "Ion Ionescu de la Brad" University of Agricultural Sciences and Veterinary Medicine, Iași en_US
dc.subject infectious diseases en_US
dc.subject human viruses en_US
dc.subject mouse models en_US
dc.subject humanized mice en_US
dc.subject transgenic mice en_US
dc.title Humanized mouse models and human viruses en_US
dc.type Article en_US Șerban Moroșan, INSERM, Sorbonne University, 91, Bd de l'Hôpital, 75634, Paris, Franta Șerban Moroșan, Andreea Paula Cozma, Mihaela Anca Dascalu, Sorin Pașca, ”Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, Iaşi
dc.publicationName Lucrări Ştiinţifice USAMV - Iaşi Seria Medicină Veterinară
dc.volume 63
dc.issue 3
dc.publicationDate 2020
dc.startingPage 235
dc.endingPage 239
dc.identifier.eissn 2393-4603

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